Journal
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
Volume 112, Issue 3, Pages 502-512Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.17269/s41997-020-00435-x
Keywords
Viral hepatitis; Validation study; Health administrative data; Immigrants
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [NHC-142832]
- Public Health Agency of Canada (PHAC)
- CanHepC
- Ontario Graduate Studentship award
- University of Toronto
- Public Health Ontario (PHO)
- ICES - Ontario Ministry of Health and Long-Term Care (MOHLTC)
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This study validated the use of HBV and HCV diagnosis codes for identifying infections, finding high specificity but low sensitivity. Diagnostic models consistently outperformed prognostic models, with no major differences observed among subgroups.
Objective We aimed to determine the criterion validity of using diagnosis codes for hepatitis B virus (HBV) and hepatitis C virus (HCV) to identify infections. Methods Using linked laboratory and administrative data in Ontario, Canada, from January 2004 to December 2014, we validated HBV/HCV diagnosis codes against laboratory-confirmed infections. Performance measures (sensitivity, specificity, and positive predictive value) were estimated via cross-validated logistic regression and we explored variations by varying time windows from 1 to 5 years before (i.e., prognostic prediction) and after (i.e., diagnostic prediction) the date of laboratory confirmation. Subgroup analyses were performed among immigrants, males, baby boomers, and females to examine the robustness of these measures. Results A total of 1,599,023 individuals were tested for HBV and 840,924 for HCV, with a resulting 41,714 (2.7%) and 58,563 (7.0%) infections identified, respectively. HBV/HCV diagnosis codes +/- 3 years of laboratory confirmation showed high specificity (99.9% HBV; 99.8% HCV), moderate positive predictive value (70.3% HBV; 85.8% HCV), and low sensitivity (12.8% HBV; 30.8% HCV). Varying the time window resulted in limited changes to performance measures. Diagnostic models consistently outperformed prognostic models. No major differences were observed among subgroups. Conclusion HBV/HCV codes should not be the only source used for monitoring the population burden of these infections, due to low sensitivity and moderate positive predictive values. These results underscore the importance of ongoing laboratory and reportable disease surveillance systems for monitoring viral hepatitis in Ontario.
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