4.6 Article

Enantiospecific deoxyfluorination of cyclic α-OH-β-ketoesters

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 1, Pages 162-165

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob02152k

Keywords

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Funding

  1. Austrian Science Funds (FWF) - Austrian National Foundation for Research, Technology and Development [P30237, P31784]
  2. Austrian Science Funds (FWF) - Research Department of the State of Upper Austria [P30237, P31784]
  3. European Union through the EFRE INTERREG IV ETC-AT-CZ program [M00146]

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The deoxyfluorination of cyclic alpha-hydroxy-beta-ketoesters using DAST reported in this study demonstrates high levels of stereospecificity, resulting in the configurationally inverted alpha-fluoro-beta-ketoesters in high yields under simple operation conditions.
We herein report the deoxyfluorination of cyclic alpha-hydroxy-beta-ketoesters using diethylaminosulfur trifluoride (DAST). The reaction proceeds with excellent levels of stereospecificity, giving the configurationally inverted alpha-fluoro-beta-ketoesters in high yields under operationally simple conditions.

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