Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 1, Pages 123-140Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01677b
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Funding
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [802736 MORPHEUS]
- Boehringer Ingelheim Stiftung (Exploration Grant Engina)
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Marine bacteria are valuable sources of structurally unique bioactive natural products, with recent studies focusing on novel compounds from various classes and their biosynthetic pathways such as fatty acids, terpenes, PKS, NRPS, and hybrid PKS-NRPS biomolecules.
Marine bacteria are excellent yet often underexplored sources of structurally unique bioactive natural products. In this review we cover the diversity of marine bacterial biomolecules and highlight recent studies on structurally novel natural products. We include different compound classes and discuss the latest progress related to their biosynthetic pathway analysis and engineering: examples range from fatty acids over terpenes to PKS, NRPS and hybrid PKS-NRPS biomolecules.
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