Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 1, Pages 109-112Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc06169g
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Funding
- CSIR, New Delhi
- KVPY
- SERB (DST Nano-mission) [DST/NM/NB/2018/16]
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Dual enzyme-responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. Temporal control of cargo release is enabled by the enzyme-responsive morphology change of the M6P lipid assembly.
Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be temporally controlled due to the enzyme responsive morphology change of the M6P lipid assembly.
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