Journal
FOOD & FUNCTION
Volume 12, Issue 1, Pages 397-407Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo01873b
Keywords
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Funding
- National Key Research and Development Program of China [2019YFE0106000, 2017YFC1600405]
- National Natural Science Foundation of China [31471647, 21866021]
- Postgraduate Innovation Special Fund Project of Jiangxi Province [YC2018-S010]
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The study demonstrated that Ganoderma atrum polysaccharide (PSG-1) has protective effects against acrylamide-induced liver, spleen, kidneys, and intestine damage in rats by alleviating inflammatory response and oxidative stress, and protecting intestinal integrity and barrier function.
In this study, the protective effects of the Ganoderma atrum polysaccharide (PSG-1) on selected tissue (liver, spleen, kidneys and intestine) toxicity induced by acrylamide (AA) in SD rats were investigated. The results showed that pretreatment with PSG-1 could prevent AA-induced damage to liver and kidney functions by increasing the activities of ALT, AST and ALP and the levels of TG, BUN and CR in the serum of AA-treated rats. PSG-1 could also maintain the intestinal barrier function and permeability by preventing the reduction of the serum d-Lac and ET-1 levels in the intestine of AA-treated rats. In addition, AA-induced DNA damage, as indicated by an increase of the 8-OHdG level, was alleviated by pretreatment with PSG-1. Histological observations of the tissues confirmed the protective effects of different doses of PSG-1. Moreover, PSG-1 supplementation reduced oxidative stress and inflammation in rats by upregulating the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and IL-10 levels, and preventing the overproduction of malondialdehyde (MDA), IL-1 beta, IL-6, and TNF-alpha. Thus, these findings suggest that PSG-1 effectively prevents AA-induced damage in the liver, spleen, kidneys, and intestine of rats, partially by alleviating the inflammatory response and oxidative stress and protecting the intestinal integrity and barrier function.
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