Journal
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
Volume 103, Issue 2, Pages 184-198Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02772248.2021.1942472
Keywords
Tartrazine; crocin; oxidative stress; malondialdehyde; ileum; colon
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The study demonstrated that crocin can alleviate tartrazine-induced oxidative damage in intestinal tissues and restore reduced antioxidant parameters. Furthermore, crocin also ameliorates tissue histopathological changes induced by tartrazine.
Tartrazine is used in the pharmaceutical, cosmetic, and food industries worldwide, despite its many toxic effects. The therapeutic effects of crocin (50mg/kg/day) against tartrazine-induced (500mg/kg/day) oxidative damage in ileum and colon tissues in rats have been investigated. Malondialdehyde and total oxidant status levels elevated by tartrazine within the ileum and colon tissues were reduced with crocin treatment, while tartrazine decreased antioxidative parameters (glutathione, total antioxidant status, superoxide dismutase, and catalase) were reverted. Tartrazine-induced histopathological changes of ileum and colon tissues were ameliorated following crocin treatment. In conclusion, Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.
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