Journal
MICROBIAL CELL
Volume 8, Issue 1, Pages 1-16Publisher
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/mic2021.01.739
Keywords
Bacillus subtilis; sporulation; genetics; SpolliE; SpollIA; SpollQ; sporulation history.
Categories
Funding
- ERC [853323]
- European Research Council (ERC) [853323] Funding Source: European Research Council (ERC)
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This review highlights foundational discoveries in endospore formation and recent rapid progress in understanding the cell biology of sporulation, while also pointing out that there are still many unexplored areas in the general aspects of sporulation.
Endospore formation has been a rich field of research for more than a century, and has benefited from the powerful genetic tools available in Bacillus subtilis. In this review, we highlight foundational discoveries that shaped the sporulation field, from its origins to the present day, tracing a chronology that spans more than one hundred eighty years. We detail how cell-specific gene expression has been harnessed to investigate the existence and function of intercellular proteinaceous channels in sporulating cells, and we illustrate the rapid progress in our understanding of the cell biology of sporulation in recent years using the process of chromosome translocation as a storyline. Finally, we sketch general aspects of sporulation that remain largely unexplored, and that we envision will be fruitful areas of future research.
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