Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 1, Pages 101-105Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01238f
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Funding
- Natural Science Foundation of China [21776254]
- Natural Science Foundation of Zhejiang Province [LQ 20B060006]
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An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed, allowing for selective activation of different types of d-C(sp(3))-H bonds in alcohols and providing a new platform for diverse functionalizations of alcohols and heteroaryls.
An efficient silver-catalyzed d-regioselective C(sp(3))-H heteroarylation of free alcohols has been developed. Various alcohols reacted with quinolines, isoquinoline, pyridines, pyrimidine, phthalazine, 4-hydroxyquinazoline, acridine, quinoxaline and pyrazine to give the corresponding C(sp(2))-H alkylation products in 31-89% yields. Notably, all types (1 degrees, 2 degrees, and 3 degrees) of d-C(sp(3))-H bonds in the alcohols could be regioselectively activated. This protocol provides a platform to access divergent functionalizations of alcohols and heteroaryls by forming the challenging d-selective C(sp(3))-C(sp(2)) bond.
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