4.8 Article

Photochemical metal-free aerobic oxidation of thiols to disulfides

Journal

GREEN CHEMISTRY
Volume 23, Issue 1, Pages 546-551

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0gc03818k

Keywords

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Funding

  1. Hellenic Foundation for Research and Innovation (HFRI)
  2. 1st Call for H.F.R.I. Research Projects [655]
  3. Hellenic Foundation for Research and Innovation (HFRI) [721]
  4. COST Action C-H Activation in Organic Synthesis (CHAOS) [CA15106]

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A new photochemical approach for the synthesis of symmetrical and non-symmetrical disulfides is described, utilizing mild, inexpensive and green conditions. The method involves the use of phenylglyoxylic acid as the photoinitiator, household bulbs as the light source, and a simple inorganic salt as the additive, resulting in excellent yields of the products.
Thiol oxidation to disulfides is an area of great importance in organic synthesis, both for synthetic and biological purposes. Herein, we report a mild, inexpensive and green photochemical approach for the synthesis of both symmetrical and non-symmetrical disulfides, using metal-free and environmentally friendly conditions. Utilizing phenylglyoxylic acid as the photoinitiator, common household bulbs as the light source and a simple inorganic salt as the additive, a versatile oxidation of thiols leading to products in excellent yields is described.

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