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Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 1, Pages 169-191

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01157f

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Funding

  1. Graduate School of University of Wisconsin-Milwaukee [RGI-101X351]

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The discovery of 3-hydroxy-2-aryl acrylate has been a significant breakthrough, serving as a pivotal building block in the synthesis of bioactive compounds and essential drugs. This scaffold, with its electrophilic and nucleophilic centers, plays a crucial role in various chemical fields.
The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydroxy-2-aryl acrylate is a vital precursor in the synthesis of natural products and in the development of essential drugs. In this first review, we outline different approaches for preparing 3-hydroxy-2-aryl acrylate with mechanisms and its application in a variety of chemical fields.

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