Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 1, Pages 77-81Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01291b
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- Czech Academy of Sciences [RVO: 61388963]
- Czech Science Foundation [18-00215J]
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The oxidative nucleophilic aromatic substitution of hydrogen in nitroaromatics with potassium alkoxides derived from primary, secondary, or tertiary alcohols in the presence of oxygen was achieved. The products showed good reactivity in nucleophilic aromatic substitution of the nitro group with oxygen or nitrogen nucleophiles to access selectively substituted aromatic compounds.
Oxidative nucleophilic aromatic substitution of hydrogen in nitroaromatics with potassium alkoxides derived from primary, secondary or tertiary alcohols in the presence of oxygen was achieved. Mechanistic investigations suggest the formation of a deprotonated sigma(H) adduct. The products showed good reactivity in nucleophilic aromatic substitution of the nitro group with oxygen or nitrogen nucleophiles to access selectively substituted aromatic compounds.
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