Journal
THERAPEUTIC DELIVERY
Volume 12, Issue 1, Pages 21-36Publisher
FUTURE SCI LTD
DOI: 10.4155/tde-2020-0099
Keywords
burst release; controlled release; drug-delivery system; drug diffusion; Korsmeyer-Peppas model; mathematical modeling; nanocarrier; nanomedicine; pulsatile release system; targeted delivery
Categories
Funding
- UCD Research
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This paper focuses on the burst release of drugs in nanocarriers, investigates its causes, examines mathematical models to explain this untimely release, revisits current techniques of limiting burst release, and prioritizes future directions to reduce such occurrences.
Burst release of encapsulated drug with release of a significant fraction of payload into release medium within a short period, both in vitro and in vivo, remains a challenge for translation. Such unpredictable and uncontrolled release is often undesirable, especially from the perspective of developing sustained-release formulations. Moreover, a brisk release of the payload upsets optimal release kinetics. This account strives toward understanding burst release noticed in nanocarriers and investigates its causes. Various mathematical models to explain such untimely release were also examined, including their strengths and weaknesses. Finally, the account revisits current techniques of limiting burst release from nanocarriers and prioritizes future directions that harbor potential of fruitful translation by reducing such occurrences.
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