Sc(OTf)3-catalyzed [3+2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)(3)-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields.

Automated summary

An efficient method has been developed to access functionalized (2,3-dihydroisoxazol-4-yl) ketones by reacting nitrones with ynones or terminal ynones in a one-pot fashion, resulting in moderate to good yields.