Journal
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
Volume 35, Issue 1, Pages 354-365Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13102818.2020.1868333
Keywords
HER2+breast cancer; Naringi crenulata extract; ultrasound-assisted extraction; apoptosis
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This study found that the Naringi crenulata extract showed significant cytotoxicity on HER2+ human breast cancer cells, with an IC50 value of 24.59 μg/mL. The NCE demonstrated anticancer potential by stimulating the cellular death of cancerous cells.
The present research aimed to screen and evaluate the anticancer effect of Naringi crenulata phytocompounds on HER2+ human breast cancer cells. The cytotoxicity assay was performed to select effective solvent extraction. Extracted compounds showed lower toxicity on normal breast cells and significant cytotoxicity on human HER2+ breast cancer cells (SK-BR3) with an IC50 value of 24.59 mu g/mL. The results indicate that the Naringi crenulata extract (NCE) shows anticancer potential via stimulating the cellular death of cancerous cells. The findings of the present study thus suggest that NCE supplementation might help in the treatment of HER2+ breast cancer.
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