Journal
CHINESE CHEMICAL LETTERS
Volume 32, Issue 1, Pages 243-257Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.11.029
Keywords
Polymeric micelles; Drug delivery; Preparation; Clinical application; Challenges
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Funding
- Fundamental Research Funds for the Central Universities [201964018]
- National Natural Science Foundation of China [31872754]
- Qingdao Program for Original Innovation and Fundamental Research [18-2-2-73-jch]
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Polymeric nanomedicine, especially polymeric micelles (PM) with nanoscale size, shows promising physical and biological advantages such as excellent solubility, pharmacokinetics, efficacy, and lower toxicity. PM has garnered increasing interest in research and clinical applications, with good clinical outcomes but also facing challenges.
Polymeric nanomedicine is a promising and rapidly evolving field. Among the different polymeric carriers, polymeric micelle (PM) with nanoscale size exhibit potent physical and biological advantages including excellent solubility and pharmacokinetics, enhanced efficacy and lower toxicity. PM has garnered increasing interest in research and in the clinic. This review will highlight the clinical outcomes of several PM-based formulations, and further summarized their preparation methods, strengths and challenges. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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