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The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking
Claire Robertson
EXPERIMENTAL CELL RESEARCH (2016)
Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma
Christopher C. DuFort et al.
GASTROENTEROLOGY (2016)
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver
Barbara Gruenwald et al.
GASTROENTEROLOGY (2016)
Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK
Shawn P. Carey et al.
INTEGRATIVE BIOLOGY (2016)
Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma
Elisabete F. Carapuca et al.
JOURNAL OF PATHOLOGY (2016)
The extracellular matrix: Tools and insights for the omics era
Alexandra Naba et al.
MATRIX BIOLOGY (2016)
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
Hanane Laklai et al.
NATURE MEDICINE (2016)
Integrin-based therapeutics: biological basis, clinical use and new drugs
Klaus Ley et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma
Andrew H. Ko et al.
PANCREAS (2016)
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
Ainhoa Arina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels
Sungmin Nam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
Caroline P. Le et al.
NATURE COMMUNICATIONS (2016)
Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
Benjamin Le Calve et al.
ONCOTARGET (2016)
Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer
Ken Takai et al.
ONCOTARGET (2016)
Stromal Myofibroblasts Are Associated with Poor Prognosis in Solid Cancers: A Meta-Analysis of Published Studies
Liu Liu et al.
PLOS ONE (2016)
Increased peri-ductal collagen micro-organization may contribute to raised mammographic density
James C. McConnell et al.
BREAST CANCER RESEARCH (2016)
The biology and function of fibroblasts in cancer
Raghu Kalluri
NATURE REVIEWS CANCER (2016)
Mechanisms of Cancer Cell Dormancy-Another Hallmark of Cancer?
Albert C. Yeh et al.
CANCER RESEARCH (2015)
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
Bryan W. Miller et al.
EMBO MOLECULAR MEDICINE (2015)
Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies
Ines Cardoso et al.
FEBS JOURNAL (2015)
Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
Daniel V. T. Catenacci et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk
Michael S. Shawky et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2015)
Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix
Megan Gessel et al.
JOURNAL OF MASS SPECTROMETRY (2015)
BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote rnorphogenesis and tissue remodeling
Sandrine Vadon-Le Goff et al.
MATRIX BIOLOGY (2015)
Matrix metalloproteinases in stem cell regulation and cancer
Kai Kessenbrock et al.
MATRIX BIOLOGY (2015)
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo et al.
MATRIX BIOLOGY (2015)
Endostatin Has ATPase Activity, Which Mediates Its Antiangiogenic and Antitumor Activities
Shan Wang et al.
MOLECULAR CANCER THERAPEUTICS (2015)
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Thomas R. Cox et al.
NATURE (2015)
FAK signaling in human cancer as a target for therapeutics
Brian Y. Lee et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Endostatin: A novel inhibitor of androgen receptor function in prostate cancer
Joo Hyoung Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Profile of nintedanib in the treatment of solid tumors: the evidence to date
Niranjan Awasthi et al.
ONCOTARGETS AND THERAPY (2015)
Substrate stress relaxation regulates cell spreading
Ovijit Chaudhuri et al.
NATURE COMMUNICATIONS (2015)
Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes
J. P. Webber et al.
ONCOGENE (2015)
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
Oakley C. Olson et al.
NATURE REVIEWS CANCER (2015)
High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium
Cecilia W. Huo et al.
BREAST CANCER RESEARCH (2015)
Damage to Skin Extracellular Matrix Induced by UV Exposure
Rachel E. B. Watson et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Cysteine cathepsins and extracellular matrix degradation
Marko Fonovic et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening
Thuy V. Nguyen et al.
BIOMATERIALS (2014)
Ionizing radiation induces tumor cell lysyl oxidase secretion
Colette J. Shen et al.
BMC CANCER (2014)
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
Berna C. Oezdemir et al.
CANCER CELL (2014)
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Andrew D. Rhim et al.
CANCER CELL (2014)
Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis
Manuel Valiente et al.
CELL (2014)
Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis
Thomas R. Cox et al.
CLINICAL CANCER RESEARCH (2014)
N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue
Annalisa Nicastri et al.
JOURNAL OF PROTEOME RESEARCH (2014)
Remodelling the extracellular matrix in development and disease
Caroline Bonnans et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1
X. Wu et al.
ONCOGENE (2014)
Flipping the Switch: Integrin Switching Provides Metastatic Competence
Aasakiran Madamanchi et al.
SCIENCE SIGNALING (2014)
Collagen as a double-edged sword in tumor progression
Min Fang et al.
TUMOR BIOLOGY (2014)
The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumor microenvironment and opportunities for novel cancer therapeutics
Edward Hammond et al.
FRONTIERS IN ONCOLOGY (2014)
Mechanotransduction Pathways Promoting Tumor Progression Are Activated in Invasive Human Squamous Cell Carcinoma
S. Jan Ibbetson et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis
Ann-Marie Baker et al.
CANCER RESEARCH (2013)
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis (Publication with Expression of Concern. See vol. 79, pg. 5124, 2019)
Thomas R. Cox et al.
CANCER RESEARCH (2013)
Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-β-Deficient Mouse Mammary Carcinomas
Michael W. Pickup et al.
CANCER RESEARCH (2013)
Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Shingo Kozono et al.
CANCER RESEARCH (2013)
Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Daniele M. Gilkes et al.
CANCER RESEARCH (2013)
Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Ludivine Bochet et al.
CANCER RESEARCH (2013)
Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer
Sofia Torres et al.
CLINICAL CANCER RESEARCH (2013)
Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)
Alyssa Charrier et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2013)
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Michael A. Jacobetz et al.
GUT (2013)
Matrix Metalloproteinase Mmp-1a Is Dispensable for Normal Growth and Fertility in Mice and Promotes Lung Cancer Progression by Modulating Inflammatory Responses
Miriam Fanjul-Fernandez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis
Daniele M. Gilkes et al.
MOLECULAR CANCER RESEARCH (2013)
The perivascular niche regulates breast tumour dormancy
Cyrus M. Ghajar et al.
NATURE CELL BIOLOGY (2013)
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Dereck Amakye et al.
NATURE MEDICINE (2013)
NAFLD, NASH and liver cancer
Gregory A. Michelotti et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
A-M Baker et al.
ONCOGENE (2013)
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
Albrecht Neesse et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Evaluation of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer Using Ultrasound Elastography
Omar Falou et al.
TRANSLATIONAL ONCOLOGY (2013)
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Vikash P. Chauhan et al.
NATURE COMMUNICATIONS (2013)
Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness
Wei Mu et al.
NEOPLASIA (2013)
Mechanistic links between COPD and lung cancer
A. McGarry Houghton
NATURE REVIEWS CANCER (2013)
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential
S. Patricia Becerra et al.
NATURE REVIEWS CANCER (2013)
Discoidin domain receptor tyrosine kinases: new players in cancer progression
Rajeshwari R. Valiathan et al.
CANCER AND METASTASIS REVIEWS (2012)
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
Alexandra Naba et al.
MOLECULAR & CELLULAR PROTEOMICS (2012)
Comprehensive care and care at the center of the new recommendation HAS
Elisa Derrien
ACTUALITES PHARMACEUTIQUES (2012)
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
Min Yu et al.
NATURE (2012)
GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells
I. M. Chu et al.
ONCOGENE (2012)
Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners
Juliette Sage et al.
PLOS ONE (2012)
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy
Christelle P. El-Haibi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The rationale for targeting the LOX family in cancer
Holly E. Barker et al.
NATURE REVIEWS CANCER (2012)
Significance of Heparanase in Cancer and Inflammation
Israel Vlodavsky et al.
CANCER MICROENVIRONMENT (2012)
Interactions between cancer stem cells and their niche govern metastatic colonization
Ilaria Malanchi et al.
NATURE (2012)
Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer
Arunee Dechaphunkul et al.
INTERNATIONAL JOURNAL OF BREAST CANCER (2012)
Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
Matthew W. Conklin et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Significance of Pathologic Response to Preoperative Therapy in Pancreatic Cancer
Yun Shin Chun et al.
ANNALS OF SURGICAL ONCOLOGY (2011)
Retinoic Acid-Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-β-Catenin Signaling to Slow Tumor Progression
Fieke E. M. Froeling et al.
GASTROENTEROLOGY (2011)
Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
Soo-Hyun Kim et al.
JOURNAL OF ENDOCRINOLOGY (2011)
The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer
Ann-Marie Baker et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
Mina J. Bissell et al.
NATURE MEDICINE (2011)
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
Thordur Oskarsson et al.
NATURE MEDICINE (2011)
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
Joyce T. O'Connell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The Collagen Family
Sylvie Ricard-Blum
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Lysyl Oxidase Contributes to Mechanotransduction-Mediated Regulation of Transforming Growth Factor-β Signaling in Breast Cancer Cells
Molly A. Taylor et al.
NEOPLASIA (2011)
The physics of cancer: the role of physical interactions and mechanical forces in metastasis
Denis Wirtz et al.
NATURE REVIEWS CANCER (2011)
The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity
Keith Brew et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
Britta Weigelt et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Disruption of Laminin-Integrin-CD151-Focal Adhesion Kinase Axis Sensitizes Breast Cancer Cells to ErbB2 Antagonists
Xiuwei H. Yang et al.
CANCER RESEARCH (2010)
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kai Kessenbrock et al.
CELL (2010)
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
J. Thomas Parsons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Could stroma contribute to field cancerization?
Lin Ge et al.
MEDICAL HYPOTHESES (2010)
Paraspeckles
Archa H. Fox et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
The impact of the extracellular matrix on inflammation
Lydia Sorokin
NATURE REVIEWS IMMUNOLOGY (2010)
Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche
Janine T. Erler et al.
CANCER CELL (2009)
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental et al.
CELL (2009)
A Fresh Prospect of Extracellular Matrix Hydrolytic Enzymes and Their Substrates
M. D. Roycik et al.
CURRENT PHARMACEUTICAL DESIGN (2009)
Heparan Sulfate Proteoglycans Are Receptors for the Cell-surface Trafficking and Biological Activity of Transglutaminase-2
Alessandra Scarpellini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cell Surface Heparan Sulfate Released by Heparanase Promotes Melanoma Cell Migration and Angiogenesis
Madhuchhando Roy et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
Pierre Farmer et al.
NATURE MEDICINE (2009)
The Extracellular Matrix: Not Just Pretty Fibrils
Richard O. Hynes
SCIENCE (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue
Dale S. Cornett et al.
ANALYTICAL CHEMISTRY (2008)
The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma
Mert Erkan et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2008)
Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification
Fawzy A. Saad et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Regulation of breast cancer response to chemotherapy by fibulin-1
Serenella M. Pupa et al.
CANCER RESEARCH (2007)
Collagen reorganization at the tumor-stromal interface facilitates local invasion
Paolo P. Provenzano et al.
BMC MEDICINE (2006)
Cathepsin S promotes human preadipocyte differentiation:: Possible involvement of fibronectin degradation
Soraya Taleb et al.
ENDOCRINOLOGY (2006)
β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
Wenjun Guo et al.
CELL (2006)
Structure and function of matrix metalloproteinases and TIMPs
H Nagase et al.
CARDIOVASCULAR RESEARCH (2006)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
RN Kaplan et al.
NATURE (2005)
Associations of ErbB2, β1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines
MM Mocanu et al.
CANCER LETTERS (2005)
Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
MD Amatangelo et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with αvβ3 and αvβ3 integrins
C Magnon et al.
CANCER RESEARCH (2005)
Phase I trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer
JR Goffin et al.
CLINICAL CANCER RESEARCH (2005)
Excisional surgery for cancer cure: therapy at a cost
JC Coffey et al.
LANCET ONCOLOGY (2003)
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
MJ Moore et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis
J Myllyharju
MATRIX BIOLOGY (2003)
Loss of types XV and XIX collagen precedes basement membrane invasion in ductal carcinoma of the female breast
PS Amenta et al.
JOURNAL OF PATHOLOGY (2003)
Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer
S Stadlmann et al.
EUROPEAN JOURNAL OF CANCER (2003)
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions
J Sottile et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
S Hiratsuka et al.
CANCER CELL (2002)
Degradation of extracellular matrix protein tenascin-C by cathepsin B: An interaction involved in the progression of gliomas
JX Mai et al.
BIOLOGICAL CHEMISTRY (2002)
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
SR Bramhall et al.
BRITISH JOURNAL OF CANCER (2002)
Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
SR Bramhall et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans
KJ Bame
GLYCOBIOLOGY (2001)
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
G Bergers et al.
NATURE CELL BIOLOGY (2000)
Two RGD-independent αvβ3 integrin binding sites on tumstatin regulate distinct anti-tumor properties
Y Maeshima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins
PS Amenta et al.
HUMAN PATHOLOGY (2000)
Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
SS Akimov et al.
JOURNAL OF CELL BIOLOGY (2000)