Journal
ACS APPLIED POLYMER MATERIALS
Volume 3, Issue 1, Pages 410-417Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.0c01173
Keywords
poly(N-isopropylacrylamide); pNIPAm-based microgels; light/heat responsivity; O-nitrobenzyl ester; triggered small-molecule release
Funding
- University of Alberta (the Department of Chemistry)
- University of Alberta (Faculty of Science)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Foundation for Innovation (CFI)
- Alberta Advanced Education & Technology Small Equipment Grants Program (AET/SEGP)
- Grand Challenges Canada
- Alberta Innovates Technology Futures for a Graduate Student Scholarship
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The light- and temperature-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) microgels demonstrated efficient release of fluorescein through UV irradiation-induced cleavage and heating-induced deswelling, showing potential applications in triggered cargo release systems.
Light- and temperature-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) (pNIPAm-co-NBMA) microgels were synthesized via free-radical precipitation polymerization and exhibited a hydrodynamic diameter of 320 +/- 40 nm. We demonstrated that the microgels' NMBA groups were cleaved upon UV irradiation, which we showed could be used for light-activated release of fluorescein (used as a model drug molecule). Moreover, drug release could also be promoted by microgel deswelling due to heating. Specifically, the hydrophobic model drug fluorescein was incorporated into the pNIPAm-co-NBMA microgels via physical interactions, and we showed that exposure to UV light (or heating) could induce its release. Thus, the pNIPAm-co-NBMA microgels could find the use for applications requiring triggered release of cargo when needed.
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