Journal
RSC ADVANCES
Volume 11, Issue 8, Pages 4593-4597Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra00063b
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Funding
- Natural Science Foundation of Anhui [2008085MB40]
- USTC Research Funds of the Double First-Class Initiative [YD2060002003]
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A transition-metal-free decarboxylative thiolation protocol is introduced for the synthesis of a variety of functionalized aryl alkyl sulfides and C-Se bond compounds, which is successfully applied for the modification of pharmaceutical carboxylates.
A transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and alpha-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C-Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility.
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