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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
NATURE (2009)
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
Mandy J. McGeachy et al.
NATURE IMMUNOLOGY (2009)
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
Shaoguang Wu et al.
NATURE MEDICINE (2009)
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
N. J. Sullivan et al.
ONCOGENE (2009)
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu et al.
NATURE REVIEWS CANCER (2009)
Interleukin-6 Receptor Inhibition With Tocilizumab Reduces Disease Activity in Rheumatoid Arthritis With Inadequate Response to Disease-Modifying Antirheumatic Drugs The Tocilizumab in Combination With Traditional Disease-Modifying Antirheumatic Drug Therapy Study
Mark C. Genovese et al.
ARTHRITIS AND RHEUMATISM (2008)
Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
Paul Trayhurn et al.
BRITISH JOURNAL OF NUTRITION (2008)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Chemokine signaling via the CXCR2 receptor reinforces senescence
Juan C. Acosta et al.
CELL (2008)
Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury
Yumiko Imai et al.
CELL (2008)
Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction
Hideki Ogura et al.
IMMUNITY (2008)
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
Xuexian O. Yang et al.
IMMUNITY (2008)
Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt
Kenji Ichiyama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
STAT3-mediated up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation
Sean A. Diehl et al.
JOURNAL OF IMMUNOLOGY (2008)
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Joshua D. Milner et al.
NATURE (2008)
Cancer-related inflammation
Alberto Mantovani et al.
NATURE (2008)
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Jeremy E. Davis et al.
OBESITY (2008)
Pancreatic carcinogenesis
Jan-Bart M. Koorstra et al.
PANCREATOLOGY (2008)
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
Preetha Anand et al.
PHARMACEUTICAL RESEARCH (2008)
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
Thomas Korn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling
Yi Tang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population
Anna Benrick et al.
REGULATORY PEPTIDES (2008)
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
Pasquale Sansone et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
Sizhi Paul Gao et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer
Charles N. Landen et al.
CANCER RESEARCH (2007)
Interleukin-6 and its receptor in cancer - Implications for translational therapeutics
David S. Hong et al.
CANCER (2007)
An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity1
Timothy J. Harris et al.
JOURNAL OF IMMUNOLOGY (2007)
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Nicholas J. Wilson et al.
NATURE IMMUNOLOGY (2007)
Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB
Xue Zhang et al.
VIROLOGY (2007)
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
Eva V. Acosta-Rodriguez et al.
NATURE IMMUNOLOGY (2007)
Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
Dennis Loeffler et al.
BLOOD (2007)
Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
Maren Luchtefeld et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma
Jonathan J. Keats et al.
CANCER CELL (2007)
Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma
Christina M. Annunziata et al.
CANCER CELL (2007)
IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
Clemens Neufert et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2007)
IL-6-gp130-STAT3 in T cells directs the development of IL-17+Th with a minimum effect on that of Treg in the steady state
Mika Nishihara et al.
INTERNATIONAL IMMUNOLOGY (2007)
Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
Brendan J. Jenkins et al.
BLOOD (2007)
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
Arian Laurence et al.
IMMUNITY (2007)
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, atiprimod
Sweeta R. Choudhari et al.
MOLECULAR CANCER THERAPEUTICS (2007)
The terminology issue for myeloid-derived suppressor cells
Dmitry I. Gabrilovich et al.
CANCER RESEARCH (2007)
Tumor exosomes inhibit differentiation of bone marrow dendritic cells
Shaohua Yu et al.
JOURNAL OF IMMUNOLOGY (2007)
Cutting edge: Regulatory T cells induce CD4(+)CD25(-)Foxp3(-) T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
LiLi Xu et al.
JOURNAL OF IMMUNOLOGY (2007)
The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivaylo I. Ivanov et al.
CELL (2006)
Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas
Yasuo Adachi et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Jason S. Stumhofer et al.
NATURE IMMUNOLOGY (2006)
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
R. N. Maini et al.
ARTHRITIS AND RHEUMATISM (2006)
Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
H-H Yeh et al.
ONCOGENE (2006)
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
E Bettelli et al.
NATURE (2006)
Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II
L Hunyady et al.
MOLECULAR ENDOCRINOLOGY (2006)
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
A Sica et al.
EUROPEAN JOURNAL OF CANCER (2006)
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
M Veldhoen et al.
IMMUNITY (2006)
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
JL Fornek et al.
BLOOD (2006)
Distinct role of macrophages in different tumor microenvironments
CE Lewis et al.
CANCER RESEARCH (2006)
IL-6-STAT3 controls intracellular MHC class II αβ dimer level through cathepsin S activity in dendritic cells
H Kitamura et al.
IMMUNITY (2005)
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
N Nishimoto et al.
BLOOD (2005)
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
Q Xu et al.
ONCOGENE (2005)
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
K Kuba et al.
NATURE MEDICINE (2005)
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling
BJ Jenkins et al.
NATURE MEDICINE (2005)
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Y Imai et al.
NATURE (2005)
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
J Campisi
CELL (2005)
The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis
K Ishihara et al.
INTERNATIONAL IMMUNOLOGY (2004)
Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
BJ Jenkins et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
SJ Park et al.
JOURNAL OF IMMUNOLOGY (2004)
Novel immunosuppressive properties of interleukin-6 in dendritic cells:: inhibition of NF-κB binding activity and CCR7 expression
S Hegde et al.
FASEB JOURNAL (2004)
Naturally arising CD4(+) regulatory T cells for immunologic self-tolerance and negative control of immune responses
S Sakaguchi
ANNUAL REVIEW OF IMMUNOLOGY (2004)
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
PC Heinrich et al.
BIOCHEMICAL JOURNAL (2003)
Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
G Cassese et al.
JOURNAL OF IMMUNOLOGY (2003)
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
G Jego et al.
IMMUNITY (2003)
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2
WD Fairlie et al.
BIOCHEMICAL JOURNAL (2003)
Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
LH Wei et al.
ONCOGENE (2003)
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
C Pasare et al.
SCIENCE (2003)
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
U Lehmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Suppressors of cytokine signaling and immunity
M Kubo et al.
NATURE IMMUNOLOGY (2003)
STAT3 is required for FIM-dependent dendritic cell differentiation
Y Laouar et al.
IMMUNITY (2003)
Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis - A randomized, double-blind, placebo-controlled, dose-escalation trial
EHS Choy et al.
ARTHRITIS AND RHEUMATISM (2002)
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
T Atsumi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
NC Tebbutt et al.
NATURE MEDICINE (2002)
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
T Yoshida et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Angiotensin converting enzyme insertion /deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome
RP Marshall et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)
Vascular inflammation and the renin-angiotensin system
AR Brasier et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
IL-6 in autoimmune disease and chronic inflammatory proliferative disease
K Ishihara et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2002)
PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
S Sun et al.
JOURNAL OF GENERAL VIROLOGY (2002)
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
I Matsumoto et al.
NATURE IMMUNOLOGY (2002)
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
GL Niu et al.
ONCOGENE (2002)
Autoimmune disease: why and where it occurs
P Marrack et al.
NATURE MEDICINE (2001)
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
M Ernst et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
SM Hurst et al.
IMMUNITY (2001)
Inflammation and cancer: back to Virchow?
F Balkwill et al.
LANCET (2001)
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
T Jostock et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
SE Nicholson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
T Hirano et al.
ONCOGENE (2000)
The role of STATs in transcriptional control and their impact on cellular function
J Bromberg et al.
ONCOGENE (2000)
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
J Schmitz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3-and SHP2-mediated signals in immune responses
T Ohtani et al.
IMMUNITY (2000)