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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
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A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
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Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
N. J. Sullivan et al.
ONCOGENE (2009)
STATs in cancer inflammation and immunity: a leading role for STAT3
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NATURE REVIEWS CANCER (2009)
Interleukin-6 Receptor Inhibition With Tocilizumab Reduces Disease Activity in Rheumatoid Arthritis With Inadequate Response to Disease-Modifying Antirheumatic Drugs The Tocilizumab in Combination With Traditional Disease-Modifying Antirheumatic Drug Therapy Study
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Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
Paul Trayhurn et al.
BRITISH JOURNAL OF NUTRITION (2008)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Chemokine signaling via the CXCR2 receptor reinforces senescence
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CELL (2008)
Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury
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CELL (2008)
Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction
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Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
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IMMUNITY (2008)
Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt
Kenji Ichiyama et al.
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STAT3-mediated up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation
Sean A. Diehl et al.
JOURNAL OF IMMUNOLOGY (2008)
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Joshua D. Milner et al.
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Cancer-related inflammation
Alberto Mantovani et al.
NATURE (2008)
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Jeremy E. Davis et al.
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Jan-Bart M. Koorstra et al.
PANCREATOLOGY (2008)
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
Preetha Anand et al.
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IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
Thomas Korn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling
Yi Tang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population
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IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
Pasquale Sansone et al.
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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
Sizhi Paul Gao et al.
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Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer
Charles N. Landen et al.
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Interleukin-6 and its receptor in cancer - Implications for translational therapeutics
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CANCER (2007)
An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity1
Timothy J. Harris et al.
JOURNAL OF IMMUNOLOGY (2007)
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Nicholas J. Wilson et al.
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Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB
Xue Zhang et al.
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Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
Eva V. Acosta-Rodriguez et al.
NATURE IMMUNOLOGY (2007)
Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
Dennis Loeffler et al.
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Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
Maren Luchtefeld et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma
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CANCER CELL (2007)
Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma
Christina M. Annunziata et al.
CANCER CELL (2007)
IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1
Clemens Neufert et al.
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IL-6-gp130-STAT3 in T cells directs the development of IL-17+Th with a minimum effect on that of Treg in the steady state
Mika Nishihara et al.
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Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
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Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, atiprimod
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The terminology issue for myeloid-derived suppressor cells
Dmitry I. Gabrilovich et al.
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Tumor exosomes inhibit differentiation of bone marrow dendritic cells
Shaohua Yu et al.
JOURNAL OF IMMUNOLOGY (2007)
Cutting edge: Regulatory T cells induce CD4(+)CD25(-)Foxp3(-) T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
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The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
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Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas
Yasuo Adachi et al.
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Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Jason S. Stumhofer et al.
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Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
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Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
H-H Yeh et al.
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
E Bettelli et al.
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Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II
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Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
A Sica et al.
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TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
M Veldhoen et al.
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Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
JL Fornek et al.
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Distinct role of macrophages in different tumor microenvironments
CE Lewis et al.
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IL-6-STAT3 controls intracellular MHC class II αβ dimer level through cathepsin S activity in dendritic cells
H Kitamura et al.
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Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
N Nishimoto et al.
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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
Q Xu et al.
ONCOGENE (2005)
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
K Kuba et al.
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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling
BJ Jenkins et al.
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Angiotensin-converting enzyme 2 protects from severe acute lung failure
Y Imai et al.
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Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
J Campisi
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The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis
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Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
BJ Jenkins et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
SJ Park et al.
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Novel immunosuppressive properties of interleukin-6 in dendritic cells:: inhibition of NF-κB binding activity and CCR7 expression
S Hegde et al.
FASEB JOURNAL (2004)
Naturally arising CD4(+) regulatory T cells for immunologic self-tolerance and negative control of immune responses
S Sakaguchi
ANNUAL REVIEW OF IMMUNOLOGY (2004)
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BIOCHEMICAL JOURNAL (2003)
Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
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JOURNAL OF IMMUNOLOGY (2003)
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
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Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2
WD Fairlie et al.
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Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
LH Wei et al.
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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
C Pasare et al.
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SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
U Lehmann et al.
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Suppressors of cytokine signaling and immunity
M Kubo et al.
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STAT3 is required for FIM-dependent dendritic cell differentiation
Y Laouar et al.
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A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
T Atsumi et al.
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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
NC Tebbutt et al.
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Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
T Yoshida et al.
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Angiotensin converting enzyme insertion /deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome
RP Marshall et al.
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AR Brasier et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
IL-6 in autoimmune disease and chronic inflammatory proliferative disease
K Ishihara et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2002)
PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells
S Sun et al.
JOURNAL OF GENERAL VIROLOGY (2002)
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
I Matsumoto et al.
NATURE IMMUNOLOGY (2002)
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
GL Niu et al.
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P Marrack et al.
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Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
M Ernst et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
SM Hurst et al.
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Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
SE Nicholson et al.
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Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
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The role of STATs in transcriptional control and their impact on cellular function
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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
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Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3-and SHP2-mediated signals in immune responses
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