Journal
EMERGING INFECTIOUS DISEASES
Volume 27, Issue 3, Pages 853-861Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2703.203110
Keywords
-
Categories
Ask authors/readers for more resources
This study identified and characterized 53 STEC strains with ExPEC-associated virulence genes isolated in Italy and the Netherlands from 2000 to 2019. The strains were divided into two major populations, each carrying different plasmids and virulence genes, indicating that ExPEC-associated plasmids can be acquired and mobilized by STEC strains.
Shiga toxin-producing Escherichia coli (STEC) O80:H2 has emerged in Europe as a cause of hemolytic uremic syndrome associated with bacteremia. STEC O80:H2 harbors the mosaic plasmid pR444_A, which combines several virulence genes, including hlyF and antimicrobial resistance genes. pR444_A is found in some extraintestinal pathogenic E. coli (ExPEC) strains. We identified and characterized 53 STEC strains with ExPEC-associated virulence genes isolated in Italy and the Netherlands during 2000-2019. The isolates belong to 2 major populations: 1 belongs to sequence type 301 and harbors diverse stx(2) subtypes, the intimin variant eae-xi, and pO157-like and pR444_A plasmids; 1 consists of strains belonging to various sequence types, some of which lack the pO157 plasmid, the locus of enterocyte effacement, and the antimicrobial resistance-encoding region. Our results showed that STEC strains harboring ExPEC-associated virulence genes can include multiple serotypes and that the pR444_A plasmid can be acquired and mobilized by STEC strains.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available