Journal
BRIEFINGS IN BIOINFORMATICS
Volume 22, Issue 2, Pages 642-663Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbaa232
Keywords
virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools
Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2016-1327, PICT 2017-2581]
- Biotechnology and Biological Sciences Research Council [BB/N018354/1, BB/S020462/1, BB/P027849/1]
- Bundesministerium fur Bildung und Forschung [5103388, 13GW0096D, 13GW0423B, 031L0176A]
- Carl Zeiss Foundation [CZS 0563-2.8/738/2]
- Deutsche Forschungsgemeinschaft [FZT 118, CRC 1076, SPP 1596]
- European Commission [H2020/777111, H2020/826078, ESF/14-BM-A55-0014/16]
- European Molecular Biology Laboratory
- Fondation Innovations en Infectiologie [R12128CC]
- National Institutes of Health [GM080219, U24HG007822, U19 AI142777-02]
- National Library of Medicine
- Swiss Federal Government through the State Secretariat for Education, Research and Innovation
- Velux Foundations [13154]
- Wellcome Trust [203783/Z/16/Z]
- Max Planck Society
- Medical Research Council [MC_UU_1201412]
- BBSRC [BB/P027849/1, BB/N018354/1, BB/S020462/1] Funding Source: UKRI
- MRC [MC_PC_19026] Funding Source: UKRI
- Wellcome Trust [203783/Z/16/Z] Funding Source: Wellcome Trust
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This review explores bioinformatics workflows and tools for the detection, analysis, tracking, evaluation, research, detection of drug targets, and development of therapeutic strategies related to SARS-CoV-2, providing valuable insights for the ongoing COVID-19 pandemic.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed as a rapid reaction to the need for fast detection, understanding and treatment of COVID-19. To control the ongoing COVID-19 pandemic, it is of utmost importance to get insight into the evolution and pathogenesis of the virus. In this review, we cover bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies. For each tool, we briefly describe its use case and how it advances research specifically for SARS-CoV-2.
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