Journal
BRAIN
Volume 144, Issue 3, Pages 781-788Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awaa411
Keywords
DBS; MEG; DTI; coherence; oscillations
Categories
Funding
- NIHR Academic Clinical Lectureship
- Academy of Medical Sciences Starter Grant
- Wellcome [203147/Z/16/Z]
- Medical Research Council [MK/K005464/1, MC_UU_12024/5]
- NIH/NINDS [2RF1NS023945-28]
- NIHR
- Michael J Fox Foundation
- Cure Parkinson's Trust
- Innovate UK
- John Black Charitable Foundation
- Janet Owens Fellowship
- Brain Research Trust [157806]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- Parkinson's Appeal
- Sainsbury Monument Trust
- Defeat MSA
- MRC [MR/K022172/1, MC_UU_12024/1, MC_UU_12024/5] Funding Source: UKRI
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Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related to dysfunction of the nucleus basalis of Meynert (NBM), with networks connecting NBM to supplementary motor area, medial temporal lobe structures, and visual areas playing important roles in motor control, memory, and visual function. The findings reveal the significance of NBM functional networks in various cognitive functions and suggest future studies to understand their contributions to disease phenotypes.
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD and DLB. Here we leverage the temporal resolution of magnetoencephalography with the spatial resolution of MRI tractography to explore the intersection of functional and structural connectivity of the NBM in a unique cohort of PDD and DLB patients undergoing deep brain stimulation of this structure. We observe that NBM-cortical structural and functional connectivity correlate within spatially and spectrally segregated networks including: (i) a beta band network to supplementary motor area, where activity in this region was found to drive activity in the NBM; (ii) a delta/theta band network to medial temporal lobe structures encompassing the parahippocampal gyrus; and (iii) a delta/theta band network to visual areas including lingual gyrus. These findings reveal functional networks of the NBM that are likely to subserve important roles in motor control, memory and visual function, respectively. Furthermore, they motivate future studies aimed at disentangling network contribution to disease phenotype.
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