Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 3, Pages 694-709Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb02655g
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Funding
- Ministry of Science and Technology, Taiwan [MOST 108-2113-M-035-001-MY3, MOST109-2113-M-006-011-MY3]
- Center of Applied Nanomedicine, National Cheng Kung University under the Featured Areas Research Center Program
- Laboratory Animal Center, College of Medicine, National Cheng Kung University
- Core Facility of Taiwan Mouse Clinic and Animal Consortium
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The newly developed nanocarrier utilizes 1550 nm light for dual-photodynamic therapy, efficiently generating singlet oxygen through activated dual-photosensitizers for enhanced anticancer effects.
The second near-infrared biological window b (NIR-IIb, 1500-1700 nm) is recently considered as the promising region for deeper tissue penetration. Herein, a nanocarrier for 1550 nm light-responsive dual-photodynamic therapy (PDT) is developed to efficiently boost singlet oxygen (O-1(2)) generation. The dual-photosensitizers (PSs), rose bengal (RB) and chlorin e6 (Ce6), are carried by the silica-coated core-shell LiYbF4:Er@LiGdF4 upconversion nanoparticles (UCNPs), forming UCNP/RB,Ce6. Following 1550 nm laser irradiation, the upconversion emission of UCNP/RB,Ce6 in both green (similar to 550 nm) and red (similar to 670 nm) colors is fully utilized to activate RB and Ce6, respectively. The simultaneous triggering of dual-PS generates an abundant amount of O-1(2) resulting in boosted PDT efficacy. This dual-PDT nanocarrier presents an enhanced anticancer effect under single dose treatment in comparison with the single-PS ones from in vitro and in vivo treatments. The marriage between the boosted dual-PDT and 1550 nm light excitation is anticipated to provide a new avenue for non-invasive therapy.
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