Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 3, Pages 857-863Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb02181d
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Funding
- National Institute of General Medical Sciences of the National Institutes of Health [R15GM114751, 2R15GM114751-02]
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A near-infrared fluorescent probe (AH+) has been developed by incorporating an oxazolidine switch into a near-infrared hemicyanine dye, showing rapid and sensitive responses to pH changes from 10.0 to 5.0. The probe exhibits good photostability, low cytotoxicity, and reversible fluorescence responses with a pK(a) value of 7.6, being successfully used for determining pH changes in mitochondria.
A near-infrared fluorescent probe (AH+) has been prepared by incorporating an oxazolidine switch into a near-infrared hemicyanine dye. The probe shows fast and sensitive responses to pH from an oxazolidine switch to the hemicyanine dye upon pH decreases from 10.0 to 5.0. The probe shows good photostability, low cytotoxicity, and reversible fluorescence responses to pH changes with a pK(a) value of 7.6. It has been successfully used to determine pH changes in mitochondria.
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