Journal
RSC ADVANCES
Volume 11, Issue 9, Pages 4952-4957Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra10218k
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Funding
- Department of Chemical Sciences at University of Padova [11NExuS_BIRD2019-UNIPD]
- MIUR [2017PBXPN4]
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Polyoxometalates (POMs) and peptides can be conjugated to form novel bio-hybrids with potential applications as nanodrugs. Functionalizing an Anderson-Evans POM with a bombesin analog peptide and adding a tailored spacer between the two moieties can enhance cancer cell recognition capability.
Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability.
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