Journal
FUTURE ONCOLOGY
Volume 13, Issue 4, Pages 347-355Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2016-0290
Keywords
cancer susceptibility; HOTAIR; long noncoding RNA; ovarian cancer; prognosis; rs920778 polymorphism
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Funding
- National Natural Science Funds [81502261, 81502262]
- Postdoctoral Science Foundation of China [2015M570634, 2015M570635, 2016T90682, 2016T90683]
- Henan Provincial Health and Family Planning Commission [201503009, 201503045]
- Postdoctoral Science Foundation of Henan Province [2014021]
- Program for Science and Technology Innovation Teams in Universities of Henan Province [17IRTSTHN021]
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Aim: The aim of this study was to determine if HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis. Materials & methods: The data were obtained from two independent groups including 329 ovarian cancer patients and 680 cancer-free, age-matched women. Blood samples were collected and genomic DNA was extracted for genotyping. Results: TT genotype and T allele of HOTAIR rs920778 were significantly associated with a decreased ovarian cancer risk (p = 0.0004 and p < 0.0001, respectively), which associated with advanced tumor stage, lymph node metastasis and poor prognosis. Moreover, TT and TC carriers obtained a much shorter survival (p = 0.026). Conclusion: These findings propose that HOTAIR rs920778 polymorphism influences ovarian cancer susceptibility and prognosis, and further studies are warranted in other populations.
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