Outcomes of Corneal Topography among Progressive Keratoconus Patients 12 months following Corneal Collagen Cross-Linking

Purpose: This study aimed to assess the overall and specific topographic changes among patients who underwent corneal collagen cross-linking (CXL) due to progressive keratoconus. Methods: This retrospective case series study was conducted at a single-arm hospital in King Abdulaziz Medical City, Riyadh. All progressive keratoconus patients who underwent CXL between January 2017 and December 2018 were included consecutively. The epi-off crosslinking technique (Dresden protocol) was applied in all patients. The topographic values were measured preoperatively and 12 months postoperatively. Patients with a history of a previous corneal procedure, corneal trauma, or any corneal scarring were excluded. Results: Among our population (29 eyes of 24 patients), 58.6% of eyes were for male patients, and the mean age of the population was 27.76 +/- 4.21 years. Based on the topography results, the mean values of corneal thickness at central 3 mm decreased from 473.45 +/- 38 mu m to 465.72 +/- 41.78 mu m following CXL (Z = -1.93, 95% confidence interval [CI] = 0.048-0.057, p= 0.053). Clinically significant astigmatism measurements were present in 28 (96.6%) eyes before CXL compared to 26 (89.7%) eyes after CXL. The mean values of astigmatism among the patients were 3.37 +/- 2.25 diopters before and 3.67 +/- 2.61 diopters after CXL (Z = -1696, 95% confidence interval [CI] = 0.085-0.096, p = 0.09). After CXL, the mean values of the front elevation at the apex changed from 33.90 +/- 20.13 mu m to 36.10 +/- 21.09 mu m (Z = -2.792, 95% [CI] = 0.003-0.006, p = 0.005). The mean values of the back elevation at the apex changed from 68.4 +/- 35.66 mu m to 69.90 +/- 35.89 mu m (Z = -0.934, 95% CI = 0.343-0.366, p = 0.35). Conclusion: The topographic corneal parameters improved significantly in the patients with corneal ectasia after CXL. These results revealed the safety and efficacy of CXL in stabilizing keratoconus progression among Saudi patients at 1 year of follow-up.

Automated summary

This study revealed significant improvement in topographic corneal parameters among patients with progressive keratoconus after corneal collagen cross-linking (CXL) treatment, demonstrating the safety and efficacy of CXL in stabilizing keratoconus progression among Saudi patients at a 1-year follow-up.