Journal
JOURNAL OF PROTEOME RESEARCH
Volume 20, Issue 3, Pages 1509-1521Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.0c00646
Keywords
psoriasis; obesity; H-1 NMR metabolomics; very-low-calorie ketogenic diet; biomarkers
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Psoriasis is an inflammatory disease associated with immunological mechanisms and obesity. Using a low-calorie ketogenic diet can effectively improve metabolic and inflammatory status in psoriasis patients.
Psoriasis is an inflammatory disease of the epidermis based on an immunological mechanism involving Langerhans cells and T lymphocytes that produce pro-inflammatory cytokines. Genetic factors, environmental factors, and improper nutrition are considered triggers of the disease. Numerous studies have reported that in a high number of patients, psoriasis is associated with obesity. Excess adipose tissue, typical of obesity, causes a systemic inflammatory status coming from the inflammatory active adipose tissue; therefore, weight reduction is a strategy to fight this pro-inflammatory state. This study aimed to evaluate how a nutritional regimen based on a ketogenic diet influenced the clinical parameters, metabolic profile, and inflammatory state of psoriasis patients. To this end, 30 psoriasis patients were subjected to a ketogenic nutritional regimen and monitored for 4 weeks by evaluating the clinical data, biochemical and clinical parameters, NMR metabolomic profile, and IL-2, IL-1 beta, TNF-alpha, IFN-gamma, and IL-4 concentrations before and after the nutritional regimen. Our data show that a low-calorie ketogenic diet can be considered a successful strategy and therapeutic option to gain an improvement in psoriasis-related dysmetabolism, with significant correction of the full metabolic and inflammatory status.
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