Journal
FUTURE ONCOLOGY
Volume 13, Issue 5, Pages 3-6Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2016-0368
Keywords
complete response; monoclonal gammopathy of undetermined significance; multiple myeloma; pomalidomide; very good partial response
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Here we discuss the case of a heavily pretreated male patient with relapsed-refractory multiple myeloma and previous monoclonal gammopathy of undetermined significance who initiated a fifth-line treatment with pomalidomide (4 mg orally, days 1-21 of a 28-day cycle) and low-dose dexamethasone (40 mg weekly orally). A total of 3 months later, very good partial response was achieved and complete response was maintained for 7 months. This case illustrates the field-practice experience on the benefits of pomalidomide in a relapsed-refractory multiple myeloma patient with a previous history of monoclonal gammopathy of undetermined significance. Indeed, the pomalidomide/dexamethasone regimen resulted in a longer progression-free survival compared with previous regimens and demonstrated a good long-term tolerability.
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