Journal
DOSE-RESPONSE
Volume 19, Issue 1, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1559325820982166
Keywords
adaptive response; dietary restriction; radiogenotoxicity; ionizing radiation; mice
Funding
- National Institute of Radiological Sciences
- National Institutes for Quantum and Radiological Science and Technology, Japan
- JSPS KAKENHI, Japan [25340041]
- Ministry of Education, Culture, Sport, Sciences and Technology (MEXT), Japan
- Nuclear Safety Research Association, Japan
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Radioadaptive response (RAR) reduces the detrimental effects of high-dose ionizing radiation (IR) by priming with low-dose IR, while the combination of RAR and mild dietary restriction (MDR) shows even more efficient reduction of radiogenotoxic damage. This indicates a potential strategy of combining adaptive responses with dietary interventions to increase treatment efficacy and prevent radiation risks in humans.
Radioadaptive response (RAR) describes a phenomenon in a variety of in vitro and in vivo systems that a low-dose of priming ionizing radiation (IR) reduces detrimental effects of a subsequent challenge IR at higher doses. Among in vivo investigations, studies using the mouse RAR model (Yonezawa Effect) showed that RAR could significantly extenuate high-dose IR-induced detrimental effects such as decrease of hematopoietic stem cells and progenitor cells, acute radiation hematopoietic syndrome, genotoxicity and genomic instability. Meanwhile, it has been demonstrated that diet intervention has a great impact on health, and dietary restriction shows beneficial effects on numerous diseases in animal models. In this work, by using the mouse RAR model and mild dietary restriction (MDR), we confirmed that combination of RAR and MDR could more efficiently reduce radiogenotoxic damage without significant change of the RAR phenotype. These findings suggested that MDR may share some common pathways with RAR to activate mechanisms consequently resulting in suppression of genotoxicity. As MDR could also increase resistance to chemotherapy and radiotherapy in normal cells, we propose that combination of MDR, RAR, and other cancer treatments (i.e., chemotherapy and radiotherapy) represent a potential strategy to increase the treatment efficacy and prevent IR risk in humans.
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