Journal
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
Volume 42, Issue 1, Pages 129-138Publisher
IMR PRESS
DOI: 10.31083/j.ejgo.2021.01.5423
Keywords
Ovarian cancer; Immune escape; Human leukocyte antigen class I molecule; Human leukocyte antigen-G
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The study found that HLA-G expression was present in 81.8% of ovarian cancers but not in benign ovarian tumors, while classical HLA class I antigen expression was down-regulated in 75.8% of ovarian cancers and only in 10% of benign tumors. The abnormal expression of HLA-G and down-regulation of classical HLA class I antigen in ovarian cancer may contribute to cancer cells evading the host's immune system.
Objective: To elucidate the potential role of HLA-G and classical HLA class I molecules in ovarian cancer, we researched their patterns of expression in benign and malignant ovarian tumors. Methods: In 10 benign and 33 malignant ovarian tumor tissues, HLA-G expression was determined both at the mRNA level by reverse transcriptase-polymerase chain reaction and immunohistochemical staining. The expression of classical HLA class I heavy chains were determined immunohistochemically. Results: Immunohistochemical analysis revealed the expression of HLA-G molecules in 27 of the 33 (81.8%) ovarian cancers but in none of the benign ovarian tumors. Classical HLA class I antigen expression was down-regulated in 25 out of the 33 (75.8%) ovarian cancers and in only 1 of the 10 benign ovarian tumors. HLA-G expression and classical HLA class I antigen downregulation were related to disease stage (Spearman's rho = 0.468, P= 0.001; Spearman's rho = -0.392, P= 0.005). Conclusion: Our results reveal that abnormal expression of HLA-G and down-regulation of classical HLA class I antigen in ovarian cancer may be one of the mechanisms by which cancer cells may escape host's immune system.
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