Journal
FUTURE MICROBIOLOGY
Volume 12, Issue 2, Pages 109-117Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2016-0156
Keywords
antibiotic resistance; bacterial infections; bacteriophages; clinical results; human sera; phage neutralization; phage therapy
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Funding
- Innovative bacteriophage preparation for the treatment of diabetic foot - National Centre for Research and Development [POIG. 01.03.01-02-048/12]
- Operational Program Innovative Economy
- Research and Development of Modern Technologies, Measure [POIG 01.03.01-02-003/08]
- Wroclaw Centre of Biotechnology, programme
- Leading National Research Centre (KNOW)
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Aim: The aim was to study the association between the phage neutralization of patients' sera and the clinical outcome of phage therapy (PT). Patients: About 62 patients with various bacterial infections receiving PT as well as 30 healthy volunteers were studied.Materials & methods: Antiphage activity of sera (AAS) was examined using the phage neutralization test of different types of phages before and during PT in relation to the route of phage administration and correlated with the results of PT. Results & conclusion: The analysis of the association between AAS level and clinical results indicated that the level of AAS is not correlated with the outcome of PT.
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