Synthesis, characterization and evaluation of biosynthesized Cerium oxide nanoparticle for its anticancer activity on breast cancer cell (MCF 7)

Biosynthesis of metal oxide nanoparticles using plant attracted great interest recently, due to its eco friendliness. Therefore, in the present study involves the synthesis of cerium oxide nanoparticle by using Brophyllamdaigremontianum plant ethanolic extract. The obtained powder was subsequently calcinated at 600 degrees C. Synthesized cerium oxide nanoparticles was confirmed by X-ray diffraction, Scanning electron microscopy, High resolution transmission electron microscopy, UV visible spectroscopy, Fourier transform infrared spectroscopy and Brunauer Emmett-teller (BET) measurement. To evaluate the anticancer activity of the spherical structured CeO2-Nps, it was tested towards the normal (L6) and breast cancer cell (MCF 7). It was found that Biosynthesized CeO2-Nps showed better cytotoxicity against cancerous MCF 7 cell line compared to normal L6 cell line due to its smaller size and high surface area. (C) 2019 Elsevier Ltd. All rights reserved.

Automated summary

This study synthesized cerium oxide nanoparticles using Brophyllamdaigremontianum plant ethanolic extract and found they exhibited better cytotoxicity against breast cancer cells, possibly due to their smaller size and higher surface area.