Journal
NANOSCALE HORIZONS
Volume 6, Issue 2, Pages 177-185Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nh00672f
Keywords
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Funding
- University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China [JLFS/P-101/18]
- ARG-CityU Applied Research Grant [9667160, 9667179]
- Beijing Institute of Technology Research Fund Program for Young Scholars
- National Natural Science Foundation of China [32001010]
- Young Elite Scientist Sponsorship Program of Beijing Association
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The synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT) shows superior clinical application prospects compared to single PDT or PTT. By designing and synthesizing a near-infrared (NIR) small molecule (ETTC), multiple functions such as NIR-II fluorescence imaging, photoacoustic imaging, PTT, and PDT were successfully achieved and optimized. This work provides a novel perspective for the development of efficient and versatile biomedical applications in a single molecule.
Photodynamic therapy (PDT) synergized photothermal therapy (PTT) shows superior clinical application prospects than single PDT or PTT. On the other hand, multimodal imaging can delineate comprehensive information about the lesion site and thus help to improve therapy accuracy. However, integrating all these functions into one single molecule is challenging, let alone balancing and maximizing the efficacy of each function. Herein, a near-infrared (NIR) small molecule (ETTC) with an acceptor-donor-acceptor structure was designed and synthesized by coupling rigity and flexibility to simultaneously achieve NIR-II fluorescence imaging (NIR-II FLI), photoacoustic imaging, PTT and PDT. The efficacy of each functionality was well balanced and optimized (NIR-II quantum yield: 3.0%; reactive oxygen species generation: 3.2-fold higher than ICG; photothermal conversion efficiency: 52.8%), which may be attributed to the coupling of the rigid and flexible structures in ETTC to tactically manipulate the energy dissipation paths (non-radiative against radiative decay). As a proof-of-concept, under the effective guidance of local-tumor imaging by PA and whole-body imaging by NIR-II FL, complete tumor eradication was achieved via PDT and PTT combinational therapy. This work provides a novel perspective into conceiving and developing single molecule for efficient versatile biomedical applications.
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