Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 9, Pages 2015-2022Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob02368j
Keywords
-
Categories
Funding
- University Grants Commission (UGC), New Delhi (India)
- CSIR, New Delhi
Ask authors/readers for more resources
Novel N-methylated ebselenamine antioxidants exhibit excellent chain-breaking and GPx-like activities, better than alpha-tocopherol, and have therapeutic potential against diseases caused by autoxidation. They can scavenge ROS with low toxicity effects and provide protection from cell death to mammals.
Novel N-methylated ebselenamine antioxidants were prepared from the corresponding diselenides with iodomethane. All ebselenamines showed excellent chain-breaking and glutathione peroxidase (GPx)-like activities. They could also inhibit lipid peroxidation much more efficiently than alpha-tocopherol. They could also mimic the functions of the GPx-enzymes nearly two times better than ebselen in the coupled reductase assay. Also, they were found to scavenge the ROS produced at low concentration (10 mu M) with low toxicity effects and could have therapeutic potential against autoxidation. It is anticipated that these compounds could potentially be used against several diseases caused by autoxidation, and thus provide protection from cell death to mammals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available