Catalytic and highly regenerable aminic organoselenium antioxidants with cytoprotective effects

Novel N-methylated ebselenamine antioxidants were prepared from the corresponding diselenides with iodomethane. All ebselenamines showed excellent chain-breaking and glutathione peroxidase (GPx)-like activities. They could also inhibit lipid peroxidation much more efficiently than alpha-tocopherol. They could also mimic the functions of the GPx-enzymes nearly two times better than ebselen in the coupled reductase assay. Also, they were found to scavenge the ROS produced at low concentration (10 mu M) with low toxicity effects and could have therapeutic potential against autoxidation. It is anticipated that these compounds could potentially be used against several diseases caused by autoxidation, and thus provide protection from cell death to mammals.

Automated summary

Novel N-methylated ebselenamine antioxidants exhibit excellent chain-breaking and GPx-like activities, better than alpha-tocopherol, and have therapeutic potential against diseases caused by autoxidation. They can scavenge ROS with low toxicity effects and provide protection from cell death to mammals.