Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 12, Pages 1474-1477Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc08265a
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Funding
- National Natural Science Foundation of China [22007058]
- State Key Laboratory of Microbial Technology Open Projects Fund [M2020-02]
- Qilu Young Scholar Fund of Shandong University
- Natural Science Foundation of Shandong Province [ZR2020QB165]
- Natural Science Foundation of Jiangsu Province [BK2020040889]
- National Institute of Allergy and Infectious Diseases [R01AI146210]
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Peptide epitopes from the spike protein of SARS-CoV-2 were synthesized and linked with CRM197 to immunize mice, leading to high titers of IgG antibodies that effectively neutralized SARS-CoV-2 pseudovirus. This study suggests that the identified epitopes are protective and the conjugates are promising for the development of an anti-SARS-CoV-2 vaccine.
For prevention of the coronavirus disease 2019 caused by the novel coronavirus SARS-CoV-2, an effective vaccine is critical. Herein, several potential peptide epitopes from the spike protein of SARS-CoV-2 have been synthesized and covalently linked with the cross-reactive material (CRM197). Immunization of mice with the resulting conjugates induced high titers of IgG antibodies against the spike protein. Importantly, the post-immune sera effectively neutralized SARS-CoV-2 pseudovirus, suggesting the epitopes identified are protective, and these conjugates are promising leads for anti-SARS-CoV-2 vaccine development.
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