Au@Ag nanoparticle sensor for sensitive and rapid detection of glucose

This paper reports a two-step seed-mediated synthesis of gold core@silver shell nanoparticles (Au@Ag NPs). The plasmonic properties of Au@Ag NPs were controlled through the etching effect of H2O2 generated from the oxidation of glucose. Therefore, we used Au@Ag NPs as surface-enhanced Raman scattering (SERS) substrates and 4-mercaptobenzoic acid (4-MBA) as the Raman tag to detect glucose concentration. This method exhibits a rapid detection process (5 min), a determination range from 10(-1) M to 10(-6) M and a detection limit of 10(-6) M, which indicate that Au@Ag NPs can serve as sensitive SERS sensors for clinical detection of blood sugar.

Automated summary

This paper presents a two-step seed-mediated synthesis method for gold core@silver shell nanoparticles and demonstrates their use as sensitive SERS sensors for detecting glucose concentration. The plasmonic properties of the nanoparticles are controlled through an etching effect, allowing for rapid and accurate detection within a wide range of concentrations.