Journal
CHEMICAL SCIENCE
Volume 12, Issue 6, Pages 2242-2250Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc05625a
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Funding
- National Science Foundation [19-05087]
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Microdroplets exhibit unique interfacial chemistry, accelerating reactions compared to bulk systems. This study found that carbon dioxide reacts with amines at the droplet interface to form carbamic acids. Additionally, the presence of trace amounts of water can enhance the reaction by potentially forming superacid or superbase at the water interface.
Microdroplets display distinctive interfacial chemistry, manifested as accelerated reactions relative to those observed for the same reagents in bulk. Carbon dioxide undergoes C-N bond formation reactions with amines at the interface of droplets to form carbamic acids. Electrospray ionization mass spectrometry displays the reaction products in the form of the protonated and deprotonated carbamic acid. Electrosonic spray ionization (ESSI) utilizing carbon dioxide as nebulization gas, confines reaction to the gas-liquid interface where it proceeds much faster than in the bulk. Intriguingly, trace amounts of water accelerate the reaction, presumably by formation of superacid or superbase at the water interface. The suggested mechanism of protonation of CO2 followed by nucleophilic attack by the amine is analogous to that previously advanced for imidazole formation from carboxylic acids and diamines.
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