Journal
FOOD & FUNCTION
Volume 12, Issue 3, Pages 926-951Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo02768e
Keywords
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Funding
- 2020 High Value Patent Cultivation Layout Center Project of Guangdong, China
- Science Foundation for Distinguished Young Scholars of Guangdong [2020B1515020026]
- Science and Technology Program of Guangzhou, China [201806040009, 201804010329]
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Chitosan oligosaccharides (COSs) are widely used biopolymers with various biological activities, but their structure-activity relationship requires further investigation. They are known for their biocompatibility, mucosal adhesion, and non-toxic nature.
Chitosan oligosaccharides (COSs) are widely used biopolymers that have been studied in relation to a variety of abnormal biological activities in the food and biomedical fields. Since different COS preparation technologies produce COS compounds with different structural characteristics, it has not yet been possible to determine whether one or more chito-oligomers are primarily responsible for the bioactivity of COSs. The inherent biocompatibility, mucosal adhesion and nontoxic nature of COSs are well documented, as is the fact that they are readily absorbed from the intestinal tract, but their structure-activity relationship requires further investigation. This review summarizes the methods used for COS preparation, and the research findings with regard to the antioxidant, anti-inflammatory, anti-obesity, bacteriostatic and antitumour activity of COSs with different structural characteristics. The correlation between the molecular structure and bioactivities of COSs is described, and new insights into their structure-activity relationship are provided.
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