Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 120, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111693
Keywords
Silver doped bioactive glass; Synergistic antibacterial properties; Methicillin-resistant Staphylococcus aureus; Cell viability; Cell differentiation; Calvarial bone growth
Categories
Funding
- OPIP of the NIH [P40OD011050]
- Michigan State University
Ask authors/readers for more resources
The research team developed a bioactive glass containing silver ions that inhibits bacterial growth and promotes bone cell growth and regeneration. Experimental results demonstrate that this novel material exhibits promising antibacterial and osteogenic properties in both in vitro and in vivo settings.
Infection is a significant risk factor for failed healing of bone and other tissues. We have developed a sol-gel (solution-gelation) derived bioactive glass doped with silver ions (Ag-BG), tailored to provide non-cytotoxic antibacterial activity while significantly enhancing osteoblast-lineage cell growth in vitro and bone regeneration in vivo. Our objective was to engineer a biomaterial that combats bacterial infection while maintaining the capability to promote bone growth. We observed that Ag-BG inhibits bacterial growth and potentiates the efficacy of conventional antibiotic treatment. Ag-BG microparticles enhance cell proliferation and osteogenic differentiation in human bone marrow stromal cells (hBMSC) in vitro. Moreover, in vivo tests using a calvarial defect model in mice demonstrated that Ag-BG microparticles induce bone regeneration. This novel system with dual biological and advanced antibacterial properties is a promising therapeutic for combating resistant bacteria while triggering new bone formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available