Journal
NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 4, Pages 2053-2059Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj05687a
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Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2019.26]
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The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines catalyzed by a deep eutectic solvent ([CholineCl][ZnCl2](3)) offers an atom-economic procedure with mild reaction conditions and recyclability. The mechanism was studied using HRMS (ESI) and the solvent showed high catalytic activity with good selectivity towards desired products.
The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl2](3)). The reactions proceed smoothly at low temperatures for a short reaction time without the use of toxic and volatile organic solvents. Deep eutectic solvents are capable of not only allowing multicomponent reactions to proceed in high yield but also controlling the selectivity towards desired products. The mechanistic insight was examined by HRMS (ESI) to propose a plausible mechanism. Furthermore, [CholineCl][ZnCl2](3) can be recycled in up to three consecutive cycles with an insignificant loss of catalytic activity under the optimized conditions.
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