Journal
SPORTS MEDICINE-OPEN
Volume 7, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s40798-020-00294-3
Keywords
Biomarkers; Stress; Physical training; Sweat; LC-MSMS
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT/MCTES) [PTDC/SAU-SOC/28390/2017]
- Associate Laboratory for Green Chemistry - LAQV - FCT/MCTES [UIDB/50006/2020]
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-SOC/28390/2017] Funding Source: FCT
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Intensive and continuous physical training in sports can lead to psychological and physiological stress, impacting the health and well-being of athletes. This study aimed to identify potential stress biomarkers in sweat samples, focusing on neurotransmitters and other related molecules. The developed methodology could contribute to the assessment and study of stress biomarkers in intense sports using non-invasive methods.
Background Intense and continuous physical training in sports is related with psychological and physiological stress, affecting the health and well-being of athletes. The development of non-invasive sampling methodologies is essential to consider sweat as a potential biological fluid for stress biomarker assessment. In the current work, the identification in sweat samples of potential molecules that may be used as stress biomarkers was pursued. Methods A sweat pool sample from football players after a 90-min intense training game was studied. Results An analysis method using liquid chromatography with detection by tandem mass spectrometry (LC-MSMS) to attain a screening profile of sweat composition is presented. The major focus was on neurotransmitters (e.g. monoamines and metabolites) and other biological molecules related with physical training, such as precursors of biogenic amines (phenylaniline, tyrosine, etc.). Conclusions This study allowed the identification of small biomolecules, neurotransmitters and other related molecules in sweat that are potentially associated with stress conditions. The developed methodology intends to contribute to the assessment and study of physical and psychological stress biomarkers related with intense sports using non-invasive methods.
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