Journal
JOURNAL OF BIOMEDICAL SCIENCE
Volume 28, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12929-021-00709-7
Keywords
Antibody generation; pH-responsive antibodies; Recycling antibodies; Sweeping antibodies; Tumor microenvironment; CAR-T cells
Categories
Ask authors/readers for more resources
pH-responsive antibodies show strong treatment potential as programmable engineered biologic drugs, targeting the acidified tumor microenvironment with improved spatial persistence and reduced toxicities. They can also be used in CAR-T engineering and improving drug delivery to the brain.
Therapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly explored in this field are pH-responsive antibodies capable of binding target antigens in a pH-dependent manner. We reviewed suitability and examples of these antibodies that are functionally modulated by the tumor microenvironment. Provided in this review is an update about antigens targeted by pH-responsive, sweeping, and recycling antibodies. Applicability of the pH-responsive antibodies in the engineering of chimeric antigen receptor T-cells (CAR-T) and in improving drug delivery to the brain by the enhanced crossing of the blood-brain barrier is also discussed. The pH-responsive antibodies possess strong treatment potential. They emerge as next-generation programmable engineered biologic drugs that are active only within the targeted biological space. Thus, they are valuable in targeting acidified tumor microenvironment because of improved spatial persistence and reduced on-target off-tumor toxicities. We predict that the programmable pH-dependent antibodies become powerful tools in therapies of cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available