Journal
AGING-US
Volume 13, Issue 1, Pages 424-436Publisher
IMPACT JOURNALS LLC
Keywords
triple negative breast cancer; exosome; miR-106a-5p; MSCs; HAND2-AS1
Categories
Funding
- Community screening of breast cancer [SHXH201803]
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The study revealed that miR-106a-5p promoted TNBC progression through mesenchymal stem cell-derived exosomes, while HAND2-AS1 inhibited TNBC growth by suppressing miR-106a-5p levels.
Background: Triple-negative breast cancer (TNBC) is a special type of breast cancer, its tumor cell metastasis rate is much higher than other types, and at the same time has a high rate of postoperative recurrence, which significantly threatens the health of women. Thus, it is urgent to explore a new treatment for TNBC. Results: MiR-106a-5p was up-regulated in TNBC tissues and cells, and was positively correlated with the tumor grade, which indicated poor prognosis in TNBC patients. Mesenchymal stem cells (MSCs) can transport miR106a-5p into TNBC cells via exosomes. Functional analysis showed exo-miR-106a-5p secreted by MSCs promoted tumor progression in TNBC cells. Furthermore, lncRNA HAND2-AS1 inhibited miR-106a-5p levels, and HAND2-AS1 was decreased in TNBC tissues and cells. Besides, overexpression of HAND2-AS1 reduced the secretion of exo-miR-106a-5p secretion from MSCs, thus suppressed TNBC development. Conclusion: Our study revealed that HAND2-AS1 inhibited the growth of TNBC, which were mediated by the inhibitory effects of MSC-derived exosomal miR-106a-5p.
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