Modeling the activity of the dopamine signaling pathway by combination of analog electrical circuit and mathematical approaches

This paper demonstrates the application of the system biology principles on the example of the dopamine signaling pathway in neurons. Presented model is based on two approaches - cytomorphic electronic circuits and mathematical modeling. Transcription and phosphorylation of DARPP-32 was modeled by analog circuit, based on well-known approaches presented in [1]. It was shown that application of circuit helps to receive signal oscillations that close to described ones in real biological systems. This combination on the one hand gives possibility to simplify calculations, on another to show this signaling pathway dynamics. The expected effect of changes in the functioning of calcium channels is considered, and the mathematical model of the interaction of system components is proposed. The average frequency of calcium current oscillations due to the presence of dopamine was 30 Hz in presented model, that is consistent with the literature, where the frequency of such oscillations is up to several tens of Hz. All presented results shows good correlation with known data, which already published today.

Automated summary

This study demonstrates the application of system biology principles in the dopamine signaling pathway in neurons, presenting a model based on cytomorphic electronic circuits and mathematical modeling. The model accurately captures signal oscillations in biological systems, simplifying calculations and showing pathway dynamics effectively. The proposed changes in calcium channel functioning and the mathematical model of system component interactions align well with existing literature, supporting the validity of the findings.