Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 11, Pages 2456-2460Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01657h
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Funding
- National Natural Science Foundation of China [21772066, 22001093, 21971087]
- Key-Area Research and Development Program of Guangdong Province [2020B010188001]
- Guangdong Special Support Program [2017TX04R059]
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An efficient and convenient method for the synthesis of pyrrole-fused tetracyclic skeletons is described in this study, utilizing CuI as a catalyst. The reaction involves tandem [3 + 2] cycloaddition and C-C coupling processes to form 7-membered cyclic ketones fused with pyrrole and biphenyl rings.
An efficient and convenient synthesis of pyrrole-fused tetracyclic skeletons is presented. In this protocol using CuI as a catalyst, 1,1 '-biphenyl substrates with 2-alkynoyl and 2 '-iodo groups react with isocyanoacetates to provide 7-membered cyclic ketones fused with pyrrole and biphenyl rings through tandem [3 + 2] cycloaddition and C-C coupling processes.
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