Journal
NANOSCALE
Volume 13, Issue 5, Pages 3049-3060Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr07215j
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Funding
- Excellent Young Scientists Fund [22022407]
- National Natural Science Foundation of China [21890740, 21890742]
- Special Foundation for State Major Research Program of China [2019YFC1606603]
- Major Program of the National Natural Science Foundation of China [21890740, 21890742]
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In this study, simple and biodegradable FeWOx ternary oxide nanoparticles were synthesized and surface-modified to possess both MRI/CT imaging capabilities and synergistic photothermal therapy/photodynamic therapy/chemodynamic therapy. The NPs showed excellent anticancer efficiency and precise imaging guidance in tumor microenvironment, making them a promising and versatile nanotheranostic platform.
The development of a simple and effective single constituent multifunctional nanotheranostic platform producing a multimodality diagnostic signal and curing effect is still a challenge. Herein, we synthesized simple and biodegradable FeWOx ternary oxide nanoparticles and modified their surface with RGD-PEG-NH2 (FeWOx-PEG-RGD NPs), whereby resulting NPs possessed a (T-2/T-1) switchable MRI/CT dual-modal imaging ability and synergistic photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) capacity. We showed that FeWOx-PEG-RGD NPs enabled tumor accumulation under a magnetic field drive and RGD-mediated tumor penetration and implemented PTT/PDT treatment under 980 nm laser irradiation. In an acidic tumor microenvironment (TME) with a high hydrogen peroxide (H2O2) expression, NPs degraded to release Fe3+ and Fe2+, triggering a Fenton reaction to generate OH for CDT. The released Fe2+ led to T-2/T-1 signal conversion for tracing cancer therapy, while the high X-ray attenuation coefficient of W also made it a good CT contrast agent for guided therapy. Thus, the structurally simple FeWOx-PEG-RGD was capable of mediating (T-2/T-1-weighted) MR/CT two modal imaging-guided PTT/PDT/CDT synergic therapy with a high accuracy and superb anticancer efficiency. The simple, degradable, rapid-clearance, and multifunctional FeWOx-PEG-RGD NPs provide a novel, promising, and versatile nanotheranostic platform.
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