Journal
HELIYON
Volume 7, Issue 3, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.heliyon.2021.e06436
Keywords
Langmuir monolayers; Drug-carrier composites; Cell culture; Triclisine
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Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2017-0149, PICT 2017-0524]
- Secretaria de Ciencia y Tecnica, Universidad Nacional de Rio Cuarto [SECYT-UNRC18/C297]
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Langmuir and Langmuir-Blodgett films were utilized as drug-delivery platforms for a synthetic bioinspired wound healing active compound. The study demonstrated that the methodology serves as a simple and reliable model for investigating the effects of bioactive compounds on cellular cultures. In particular, the presence of 2-methyltriclisine in the amphiphilic layers significantly impacted the proliferation and migration of normal human lung cells.
Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures.
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