Journal
COMPARATIVE MEDICINE
Volume 71, Issue 1, Pages 3-45Publisher
AMER ASSOC LABORATORY ANIMAL SCIENCE
DOI: 10.30802/AALAS-CM-20-000054
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Escherichia coli, a common bacteria in humans and animals, has different strains with varying virulence factors that can cause a range of infections. This review covers the history, hosts, clinical manifestations, epidemiology, and control of different E. coli pathotypes, providing insights for future investigations on E. coli infections in various animals, including humans, from a comparative and One Health perspective.
E. coli is one of the most common species of bacteria colonizing humans and animals. The singularity of E. coli's genus and species underestimates its multifaceted nature, which is represented by different strains, each with different combinations of distinct virulence factors. In fact, several E. coli pathotypes, or hybrid strains, may be associated with both subclinical infection and a range of clinical conditions, including enteric, urinary, and systemic infections. E. coli may also express DNA-damaging toxins that could impact cancer development. This review summarizes the different E. coli pathotypes in the context of their history, hosts, clinical signs, epidemiology, and control. The pathotypic characterization of E. coli in the context of disease in different animals, including humans, provides comparative and One Health perspectives that will guide future clinical and research investigations of E. coli infections.
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