Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 7, Pages 919-922Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc07625b
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Funding
- EPSRC [EP/P016618/1, EP/N025652/1]
- EPSRC [EP/P016618/1, EP/N025652/1] Funding Source: UKRI
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This study reports a regioselective gamma-C-H amination method for the side-chain of saturated 2-alkyl nitrogen heterocycles, which proceeds through a sulfamide-directed 1,6-radical translocation. The practicality of this rapid access to 1,3-diamines is highlighted in a short synthesis of the alkaloid tetraponerine T8 and non-natural analogues.
The regioselective gamma-C-H amination of the side-chain of saturated 2-alkyl nitrogen heterocycles is reported, proceeding through a sulfamide-directed 1,6-radical translocation. The practicality of this rapid access to 1,3-diamines is highlighted in a short synthesis of the alkaloid tetraponerine T8 and non-natural analogues.
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